Extended Data Fig. 1: Integrated personalized omics profiling cohort flow chart and genetic ancestry.
a, The flow chart demonstrates recruitment and enrollment of the iPOP cohort. b, PCA plot showing the ancestries of 72 participants. The reference includes 2,504 samples from the 1,000GP11. Each filled circle is a 1,000GP sample, colored by the super-population of ancestral origin, namely African (AFR; red), admixed American (AMR; purple), East Asian (EAS; green), European (EUR; cyan) and South Asian (SAS; orange). Each black symbol is an individual from the study, which we categorized by self-reported ethnicity consistent with the 1,000GP super-population definitions, namely AFR (black filled circle), AMR (black filled triangle), EAS (black filled square), EUR (black plus sign) and South Asian (a checked box). We see that the individuals in our study have self-reported ancestries generally clustering in the super-population reference panel from the 1,000GP.
