Extended Data Fig. 2: Comparison of diabetic metrics in categorizing individuals when performed at the same time and HbA1C trajectories.
a, Overlap of FPG and hemoglobin A1C (HbA1C) categories when simultaneously measured. FPG impaired: 1.0 mg ml−1 ≤ FPG < 1.26 mg ml−1; diabetic range: FPG ≥ 1.26 mg ml−1; HbA1C impaired: 5.7% ≤ HbA1C < 6.5%; diabetic range: HbA1C ≥ 6.5%. b, Overlap of FPG and 2-hour OGTT when simultaneously measured. FPG ranges as above. OGTT impaired: 1.40 mg ml−1 ≤ OGTT < 2.00 mg ml−1; diabetic range ≥2.00 mg ml−1. c, Longitudinal patterns of changes in Hemoglobin A1C (HbA1C) over time. Six different patterns could be characterized including: 1, participants who remained in the normal range the entire study (Group 1, n = 51); 2, participants who progressed from normal to prediabetic (Group 2, n = 5); 3, participants who went from prediabetic to normal (Group 3, n = 10); 4, participants whose HbA1C went back and forth from normal to prediabetic (Group 4, n = 21); 5, participants whose HbA1C laboratory results were predominantly in the prediabetic range (Group 5, n = 14) and 6, participants whose HbA1C crossed into the diabetic range (Group 6, n = 8). The red lines represent the overall penalized b-spline of participants’ data in each category.
