Extended Data Fig. 3: Decrease in lymphocyte count after lymphodepletion chemotherapy in individual patients.
All patients were administrated 3-d lymphodepletion chemotherapy comprising fludarabine (25 mg m–2 on days 1–3) and cyclophosphamide (250 mg m–2 on days 1–3) before CAR T cell infusion. The time point of lymphodepletion was on the day of CAR T cell infusion (day 0) for all patients, except for patients BZ015 (day –1), BZ021 (day –2) and BZ026 (day –3). Each patient’s lymphocyte counts before and after lymphodepletion chemotherapy are connected by a line for pairwise comparison. The median blood lymphocyte count just before lymphodepletion chemotherapy was 1 × 109 cells L–1 (range of 0.49–1.73 × 109 cells L–1). The median lymphocyte count after chemotherapy on the day of CAR T cell infusion was 0.14 × 109 cells L–1 (range of 0.02–0.61 × 109 cells L–1).
