Extended Data Fig. 4: Bacteriotherapy with S. variabile protects against FA.
From: Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
a, Temperature changes in SPF Il4raF709 mice that were antibiotic-treated then sensitized with OVA/SEB while receiving no treatment (n = 8) or treatment with S. variabile (n = 11), and thereafter challenged with OVA. P values were derived by two-way ANOVA. b,c, Total and OVA-specific IgE (no bacteria: n = 8; S. variabile: n = 11). d, MMCP-1 concentrations (no bacteria: n = 8; S. variabile: n = 11). e,f, Analysis of MLN ROR-γt+ and GATA3+ cells among Helios–NRP1– and Helios+NRP1+ Foxp3+ Treg cells, respectively (no bacteria: n = 8; S. variabile: n = 5). g, Analysis of MLN IL-4+ CD4+Foxp3+ Treg cells and IL-4+ CD4+Foxp3– Teff cells (no bacteria: n = 8; S. variabile: n = 5). Each dot represents one mouse. Throughout, data represent mean ± s.e.m. from two independent experiments. For b–g, P values were derived by Student’s unpaired two-tailed t-test with Welch correction.
