Extended Data Fig. 7: IL-4/IL-13- and Notch-driven gene transcription signatures in goblet cell metaplasia in asthma.
From: A cellular census of human lungs identifies novel cell states in health and in asthma
a, Violin plot depicting IL-4/IL-13 genes signature expression in each cluster of biopsy epithelial cells (signature obtained from ref. 24). b, Violin plot depicting the expression of the IL-4/IL-13 signature (as in a) in healthy control and asthma cells of selected clusters. c, Violin plot depicting Notch signature genes (HES4, HES5, HEY1, HEY2, HEYL, and NRARP) expression in each cluster of biopsy epithelial cells. d, Violin plot depicting the expression of Notch signature genes (as in c) in healthy control and asthma cells of selected clusters. e–g, Expression of secretory specific (HES4 and SPDEF) and ciliated specific (FOXJ1) transcription factors in club (e), goblet (f), ciliated (g), and mucous ciliated (h) cells. Panels a–h, n = 12 individuals. Complete sample distribution in Fig. 3b.
