Extended Data Fig. 10: A control ASO (Control-ASO) failed to reduce Rictor mRNA levels and inhibit mTORC2 activity. | Nature Medicine

Extended Data Fig. 10: A control ASO (Control-ASO) failed to reduce Rictor mRNA levels and inhibit mTORC2 activity.

From: Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency

Extended Data Fig. 10: A control ASO (Control-ASO) failed to reduce Rictor mRNA levels and inhibit mTORC2 activity.

(a) Treatment with Control-ASO did not reduce Rictor mRNA [PBS (n = 6) vs. Control-ASO (n = 4), t8 = 1.88, P = 0.0968]. Representative western blot image (b) and quantification of (c-d) show that Control-ASO did not decrease Rictor protein levels (n = 4 per group, PBS vs. control-ASO t6 = 0.57, P = 0.5864) or mTORC2 activity (n = 4 per group, PBS vs. control-ASO, t6 = 0.71, P = 0.5018). Data are mean ± SEM. Statistics were based on two-sided t-test comparisons. n.s., not significant.

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