Extended Data Fig. 5: Association between clinical outcome and the cell cycle signature at baseline. | Nature Medicine

Extended Data Fig. 5: Association between clinical outcome and the cell cycle signature at baseline.

From: Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

Extended Data Fig. 5

The cell cycle signature is calculated as the mean Z-score of the following genes: MKI67, CCNE1, BUB1, BUB1B, CCNB2, CDC25C, CDK2, MCM4, MCM6, MCM2. Median IQRs and ranges are shown. There was no significant difference between response and relapse samples (two-sided Wilcoxon rank sum test, p= 0.34). No adjustments were made for multiple comparisons. Number of samples given in parenthesis.

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