Extended Data Fig. 2: Comparing age and sex effects in independent cohorts.
From: Undulating changes in human plasma proteome profiles across the lifespan
(a) Age and sex effects in the INTERVAL and LonGenity studies (n = 4,263) were compared to age and sex effects in 4 independent cohorts analyzed together (n = 171) and to age effect from Tanaka et al. (n = 240, 2018). The aging plasma proteome was measured with the SomaScan assay in these cohorts and 888 proteins were measured in all studies (b) Scatter plot representing the signed -log10(q value) of the sex effect in the INTERVAL/LonGenity cohorts (x axis, n = 4,263) vs the 4 independent cohorts (y-axis, n = 171). Similar analysis for the age effect in the 4 independent cohorts (c, n = 171) and in Tanaka et al study (d, n = 240).
