Extended Data Fig. 4: Proteins and proteome undulations in independent human cohorts and in mouse. | Nature Medicine

Extended Data Fig. 4: Proteins and proteome undulations in independent human cohorts and in mouse.

From: Undulating changes in human plasma proteome profiles across the lifespan

Extended Data Fig. 4: Proteins and proteome undulations in independent human cohorts and in mouse.

(a) Trajectories of 5 selected proteins based on the INTERVAL and LonGenity cohorts (n = 4,263, left) and 4 independent human cohorts (n = 171, right). Trajectories were estimated using LOESS regression. Undulation of the 1,305 plasma proteins measured in 4 independent cohorts (b, n = 171) and in mouse (c, n = 81). Plasma proteins levels were z-scored and LOESS regression was fitted for each plasma factor.

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