Extended Data Fig. 8: Widespread GFP expression in pyramidal neurons of motor cortex after a single bolus cervical subpial delivery of AAV9-UBI-GFP in adult pig. | Nature Medicine

Extended Data Fig. 8: Widespread GFP expression in pyramidal neurons of motor cortex after a single bolus cervical subpial delivery of AAV9-UBI-GFP in adult pig.

From: Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

Extended Data Fig. 8: Widespread GFP expression in pyramidal neurons of motor cortex after a single bolus cervical subpial delivery of AAV9-UBI-GFP in adult pig.The alternative text for this image may have been generated using AI.

a-f, Intense GFP expression throughout the majority of pyramidal neuron population in layer V of the motor cortex at 3 weeks after a single bolus cervical subpial delivery of AAV9-UBI-GFP in an adult pig. GFP expression was not detected in glial cells localized in the molecular layer, consistent with retrograde AAV delivery to pyramidal neurons from corticospinal axons transiting through or terminating in subpially-injected cervical spinal cord segments. A representative result of 3 individual pigs is shown. ML, molecular layer.

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