Fig. 1: Solicited local and systemic reactions by different doses and time intervals between doses.

Local (top) and systemic (bottom) solicited reactions following prime and boost vaccinations at different dose regimens. Day 0, day of vaccination; P, post-vaccination observation period in the clinic. Fever was classified as mild (38.0 °C to <38.5 °C), moderate (38.5 °C to <39.0 °C) and severe (≥39.0 °C). Feverish was defined as a self-reported feeling of feverishness.