Extended Data Fig. 8: State-specific expression of sepsis signature genes. | Nature Medicine

Extended Data Fig. 8: State-specific expression of sepsis signature genes.

From: An immune-cell signature of bacterial sepsis

Extended Data Fig. 8

(a) tSNE plots showing scaled gene expression counts across all cells (n = 126,351 total from 65 individuals) for FAIM3-PLAC828 and SeptiCyte Lab22 genes ( + or - indicates that a gene is up- or down-regulated, respectively, in sepsis). (b) Mean expression of PLAC8 in T cell (top row) and monocyte (bottom row) states across patients grouped by cohort. Sample size (n) for each cohort is indicated in Fig. 1b. (c-f) Heatmaps show state-specific expression of Sepsis Metascore12 genes (c), genes previously associated with sepsis mortality (d) or survival10,11 (e), and sepsis-linked GWAS genes (f). Color scale corresponds to z-scored, log2-transformed mean gene expression counts for cell state.

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