Extended Data Fig. 3: Comparison of IGHV3-33-encoded antibodies binding to NANP and C-CSP peptide with NANA motif. | Nature Medicine

Extended Data Fig. 3: Comparison of IGHV3-33-encoded antibodies binding to NANP and C-CSP peptide with NANA motif.

From: Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

Extended Data Fig. 3: Comparison of IGHV3-33-encoded antibodies binding to NANP and C-CSP peptide with NANA motif.

a, Isothermal titration calorimetry (ITC) measurements of IGHV3-33-encoded antibodies binding to NANP3 (mAbs 2243, 2541, 3945, 4498) or a 14-aa long C-CSP peptide (PNRNVDENANANSA; mAb 3246). b, Detailed interactions between mAbs 2243 and 2541 and NANP5, mAbs 4498 and 3945 and NANP3, and mAb 3246 and NANA. H-bonds are shown as black dashes. c, Thermodynamic parameters for Fabs 1210, 2243, 2541, 3945, 4498 and 3246 binding to PfCSP peptides as determined by ITC. Experiments were performed in duplicate or triplicate. Standard error of the mean (s.e.m.) is reported. NB denotes no binding.

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