Extended Data Fig. 8: Tumor burden induces tissue-specific changes in immune cell cycling.
From: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
a-b, Log2 fold change in bulk Ki67 expressing leukocytes in each tissue tissues for 4T1, LLC and MMTV tumors (a), and over 4T1 tumor progression (b). p*< 0.05, One-Way ANOVA, with Tukey correction versus control. c-d, Statistical Scaffold maps of Ki67 expression in immune cells of the tumor draining lymph node comparing control to day 21 (c) and the Spleen over time (d) in 4T1 tumor burdened animals. e, Percent of increasing clusters (red, total of 56), decreasing clusters (blue, total of 90), or unchanged cluster that have corresponding changes in cell cycle markers Ki67 and cleaved Caspase-3.
