Fig. 3: LRRK2 pLoF variants are not strongly associated with either age distribution or any adverse phenotypes.
From: The effect of LRRK2 loss-of-function variants in humans
a, The age distributions of LRRK2 pLoF carriers are not significantly different from those of noncarriers in both gnomAD and 23andMe. Note that this analysis is based on age at sample collection. b, Manhattan plot of phenome-wide association study results for carriers of three LRRK2 pLoF variants against noncarriers in the 23andMe cohort. Each point represents a distinct phenotype, with these grouped into related categories (delineated by alternating black and gray points). The dotted horizontal line represents a Bonferroni-corrected P value threshold for 366 tests. Logistic regression was used for binary phenotypes and linear regression for quantitative phenotypes controlling for age, sex, genotyping platform and the first ten genetic principal components. Full association statistics are listed in Supplementary Table 8.
