Fig. 4: LRRK2 pLoF carriers do not have impaired lung, liver or kidney function.
From: The effect of LRRK2 loss-of-function variants in humans
For all plots, points for individual pLoF carriers are shown in teal and noncarriers in gray. The mean and 1 × s.d. are represented by the black circle and line. a, Urine biomarkers albumin and creatinine were transformed into two clinical markers of kidney function (Methods). No pLoF carriers showed signs of severely impaired kidney function. ACR, albumin to creatinine ratio. b, Z scores of age-, sex- and height-corrected spirometry measures of lung function36. FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s. c, Blood serum biomarkers of liver function. The plots for alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin and creatinine were top-truncated, removing 47, 29, 92, 8 and 27 noncarriers respectively. The violin plots and summary statistics were calculated on the full dataset. All pLoF carriers are within each plot area.
