Extended Data Fig. 10: The spectrum of plasmablast-to-granulocyte phenotype is present in patients experiencing ARDS and this putative transdifferentiation is likely unrelated to transcriptional dynamics of canonical neutrophils.
From: A single-cell atlas of the peripheral immune response in patients with severe COVID-19
a, UMAP embedding of plasmablasts and activated granulocytes faceted by COVID-19 sample. n = 3,187 cells are plotted from n = 14 biologically independent samples. b-c, UMAP embeddings of plasmablasts, activated granulocytes, and canonical neutrophils overlaid with RNA velocity stream (b) or velocity grid (c). n = 3,911 cells are plotted from n = 14 biologically independent samples.
