Extended Data Fig. 1: Carrying a P/LP variant in a FH gene leads to increased risk and earlier onset of hyperlipidemia and treatment with anti-hyperlipidemic medications.
From: Population genetic screening efficiently identifies carriers of autosomal dominant diseases
Disease-free survival for ‘carriers’ (n = 73) of a FH P/LP variant and ‘non-FH carriers’ (n = 20,117) for a, first report of a ICD-10 code for hyperlipidemia in the medical record, and b, first order for an anti-hyperlipidemic medication in the medical record. Solid colored lines (and the matching shaded regions) are survival curves with 95% confidence intervals. The dotted lines represent the median survival age. p-values represent the results of a 2-sided log-rank test. No adjustments were made for multiple comparisons.
