Extended Data Fig. 10: Quantification of the ICANS-associated cells (IACs) signature by scGSVA in CAR T-cell infusion products. | Nature Medicine

Extended Data Fig. 10: Quantification of the ICANS-associated cells (IACs) signature by scGSVA in CAR T-cell infusion products.

From: Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas

Extended Data Fig. 10

a, A stringent threshold was set to ensure high confidence classification of IACs by scGSVA analysis of the 109 signature genes measured by CapID, as shown for the cells that were originally identified as IACs by unsupervised clustering of 10X whole-transcriptome data in Fig. 4a. b, The distribution of scGSVA scores shows a clear difference between infusion products from patients with grade 0-2 ICANS vs patients with grade 3-4 ICANS. The threshold for classification of cells as IACs (scGSVA score >1.5) is shown.

Back to article page