Extended Data Fig. 5: Transcriptomic and proteomic analyses of downstream effectors of MDK.
From: Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state
a, MSigDB Hallmark Gene set collection identified by GSEA to be differentially expressed in the RNAseq of WM164-MDK vs WM164-Control melanoma cells. Data are plotted with respect to Normalized Enriched Scores (NES), with those representing downregulation and upregulation in blue and red, respectively. FDR q-value < 0.25. b, Heatmap representing differentially expressed immunomodulatory proteins secreted by WM164 MDK melanoma cells with respect to their isogenic control. Relative expression values are represented as in the scale drawn in the bottom part of the figure.
