Extended Data Fig. 7: Expression of central memory and WNT pathway genes in pre-infusion patient products.
From: Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis
a, Gene expression in pre-infusion products from patients 1-3 for TNFRSF4 (encodes OX40), SELL (encodes CD62L), and genes related to Wnt-mediated signal transduction (https://www.gsea-msigdb.org/gsea/msigdb/cards/WNT_SIGNALING.html) overlaid on the UMAP 2D projection. b, Cryopreserved patient products were thawed and rested overnight prior to evaluating surface expression of OX40 (CD134) and CD62L (bottom) by flow cytometry using the corresponding fluorochrome-conjugated isotype controls (top). c, LEF1 expression in relation to CD62L was analyzed using intracellular flow cytometry (bottom) with the corresponding PE-conjugated isotype controls (top). Results are from one of two independent experiments with similar results.
