Extended Data Fig. 2: Specificity and sensitivity of the seasonal coronavirus ELISA assays.
From: Seasonal coronavirus protective immunity is short-lasting
Left panel: specificity analysis. Forty-seven subjects infected by a respiratory virus (non-coronavirus) were tested for significant increases in anti-NCt antibodies directed to the four seasonal coronaviruses. V1 (acute symptomatic infection) and V2 (28–35 days later) sera were compared. On the Y-axis the V2/V1 OD fold change is shown and a ratio ≥ 1.40 is regarded as positive. Right panel: sensitivity analysis. Fifty-nine subjects with an RT-PCR confirmed coronavirus infection were tested for development of antibodies directed to the four seasonal coronaviruses.
