Extended Data Fig. 3: Decreased postnatal mitotic cell cycle activity and TEM survey in HMZ pig myocardium.
From: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
a, Analogous to (Fig. 1i), upper panels compare LV myocardial proliferative activity in WT and HMZ pigs at day-7 assessed by condensed chromatin/mitotic figures by H&E histochemical staining (upper panels) or pH3 F-IHC with DAPI co-stain (lower panels), individual mitotic figures highlighted by yellow circles. These results are representative of multiple repeat experiments in different animals. Scale bars, μm. b, Survey of HMZ pig myocardium at day-7 by TEM at increasing magnification from top to bottom, 2,500X-to-50,000X, respectively, highlighting multifaceted ultrastructural cellular pathology. Scale bars, μm.
