Extended Data Fig. 5: Supervised, non-SNF classification of the microbial interactome based on known exacerbation frequencies.

Network visualization of key microbial taxa in (a) non-frequent (<3 exacerbations/year) and (b) frequent (3 or more exacerbations/yr) are illustrated. Coloured circles represent microbes and grey lines their associated interactions within the network. Taxa present at >1% relative abundance in at least 5% of the patient cohort are included. Circle size (degree) reflects the number of direct interactions for a given microbe (termed ‘busy’). Circle outline thickness represents the calculated stress centrality for each microbe termed ‘critical’ while circle colour depth reflects betweenness centrality or the ‘influence’ of the microbe within the network. A table to the right of each network illustrates details the composition of busy (degree), critical (stress centrality) and influential (betweenness centrality) microbes observed in non-frequent vs frequent exacerbators. Additional microbes present in the top taxa compared to SNF-based analysis (Fig. 3a,b) are highlighted by bold typeface.