Extended Data Fig. 3: Regional association plots for cis-variants associated with ACE2 gene expression or ACE2 plasma protein levels, and their association with COVID-19 hospitalization. | Nature Medicine

Extended Data Fig. 3: Regional association plots for cis-variants associated with ACE2 gene expression or ACE2 plasma protein levels, and their association with COVID-19 hospitalization.

From: Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Extended Data Fig. 3: Regional association plots for cis-variants associated with ACE2 gene expression or ACE2 plasma protein levels, and their association with COVID-19 hospitalization.

a, rs4830976 as an eQTL for ACE2 expression in brain frontal cortex tissue (N = 175). b, rs4830976 in COVID-19 hospitalization (N = 1,377,758). c, rs5935998 as the primary pQTL for plasma ACE2 measured by Oink in 4,998 INTERVAL participants d, rs5935998 in COVID-19 hospitalization e, rs4646156 as the secondary pQTL (that is after adjusting for rs5935998) for plasma ACE2 measured by Oink in 4,998 INTERVAL participants. f, rs4646156 in COVID-19 hospitalization. a colocalizes with b (PP.H4 = 0.95), but c does not colocalize with d (PP.H4 = 0.49) and e does not colocalize with f (PP.H4 = 0.08).

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