Extended Data Fig. 4: Mean (SD) percentage change in erythropoietin (mIU/ml) from baseline for the first 8 days. | Nature Medicine

Extended Data Fig. 4: Mean (SD) percentage change in erythropoietin (mIU/ml) from baseline for the first 8 days.

From: Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis

Extended Data Fig. 4: Mean (SD) percentage change in erythropoietin (mIU/ml) from baseline for the first 8 days.

BID: twice daily; QD: once daily; SD: standard deviation. n includes patients who had a predose assessment and at least one postdose assessment. *Erythropoietin concentration from baseline for the 160-mg QD dose cohort is based on the values after excluding one patient who had a very low erythropoietin baseline measurement of 2.8 mIU/ml, which is lower than the typical lower value of normal physiological reference range (3.5 mIU/ml) and very close to the lower limit of quantitation of 2.5 mIU/ml. This possibly erroneous low baseline value resulted in apparent large increases in percentage change from baseline in all the postbaseline values for this patient.

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