Extended Data Fig. 8: Mean BMI across time with MC4R LoF of β-arrestin-2 coupling.
From: Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort
Mean BMI +/− 95% CI at different ages (sample sizes across all ages presented in Supplementary Table 14) with MC4R LoF of β-arrestin-2 (carriers of pLoF and cLoF) and the reference group (that is, non-LoF carriers – combining individuals with synonymous, common variations or no LoF mutations and individuals with WT-like and GoF mutations). Figures only show results where all mutational groups (that is, WT-like, GoF, pLoF and cLoF mutations) were represented by at least one individual at all time points between birth and 24 years. CI = confidence interval; cLoF = complete loss of function; GoF = gain of function; LoF = loss of function; pLoF = partial loss of function; WT = wild-type.
