Extended Data Fig. 6: Multiparameter co-expression profiles of activation/exhaustion markers for patient starting and final products. | Nature Medicine

Extended Data Fig. 6: Multiparameter co-expression profiles of activation/exhaustion markers for patient starting and final products.

From: Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

Extended Data Fig. 6

Boolean gating was performed for activation markers of interest before visualization via SPICE analysis software. Final-02 and Final-03 refer to second and third manufacturing attempts for S003. Two-sided permutation tests performed with 10,000 iterations per the built-in SPICE analysis function found no significant differences between samples (p > 0.05). Representative flow gating strategy shown in Supplementary Fig. 1a,b.

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