Extended Data Fig. 1: Patient Disposition. | Nature Medicine

Extended Data Fig. 1: Patient Disposition.

From: Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial

Extended Data Fig. 1: Patient Disposition.

*Cohort 1: Patients with AdvSM and ≥1 mIWG-MRT-ECNM criteria for evaluable disease (have severe and quantifiable organ damage (an evaluable C-finding) or have MCL (regardless of C-findings)) as confirmed by the SSC. Twenty patients in Cohort 1 were not included in the interim analysis efficacy population due to lack of sufficient follow-up. †Patients with AdvSM who were not considered eligible for an adjudicated response and were confirmed centrally to have ASM or SM-AHN, but were lacking an evaluable C-finding as determined by the SSC. ‡No patient discontinued from treatment due to lost to follow-up, protocol deviation, pregnancy, investigator decision, non-compliance, sponsor decision, or other reason. AdvSM, advanced systemic mastocytosis; AHN, associated hematologic neoplasm; AML, acute myeloid leukemia; ASM, aggressive systemic mastocytosis; MCL, mast cell leukemia; mIWG-MRT-ECNM, modified International Working Group-Myeloproliferative Neoplasms Research and Treatment and European Competence Network on Mastocytosis; SM-AHN, systemic mastocytosis with an associated hematologic neoplasm; SSC, study steering committee; WHO, World Health Organization.

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