Extended Data Fig. 9: Correlation between vaccine-induced protection and antibodies against specific epitopes, infected cells or ADCC.

a. Correlation between protection and antibodies against an autologous linear V3 peptide (WITO pV3). b. Correlation between protection and antibodies against a heterologous linear V3 peptide (JR-FL V3). c. Correlation between protection and antibodies against a V1V2 scaffolded protein (gp70 V1V2). d. Correlation between protection and antibodies binding to the surface of SHIV AD8-infected primary CD4⁺ T cells. The results are mean values from two experiments. The correlation becomes significant after exclusion of an outlier (macaque V7, highlighted in red). The correlation coefficient and P value with the inclusion of the outlier are indicated in red. e. Correlation between protection and antibodies mediating ADCC against SHIV AD8-infected primary CD4⁺ T cells. The results are mean values from two experiments. The correlation becomes significant after exclusion of an outlier (macaque V1, highlighted in red). The correlation coefficient and P value with the inclusion of the outlier are indicated in red. f. Inhibitory effect of a VRC01 Fab fragment on macaque antibody binding to SHIV AD8-infected primary CD4⁺ T cells. C denotes Fab-untreated controls. All correlations were determined by the Spearman test.