Extended Data Fig. 3: Induction of autologous neutralizing antibodies in the two subgroups of immunized macaques. | Nature Medicine

Extended Data Fig. 3: Induction of autologous neutralizing antibodies in the two subgroups of immunized macaques.

From: A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Extended Data Fig. 3: Induction of autologous neutralizing antibodies in the two subgroups of immunized macaques.

Subgroup 1 received 5 mRNA and 5 protein immunizations; subgroup 2 received 8 mRNA and 2 protein immunizations. a. Serum titers of neutralizing antibodies against the autologous Env (WITO4160.27), as assayed using pseudoviruses on TZM-bl cells. The sequence and timing of immunizations are indicated by color-coded triangles on the top. b. Effect of the autologous linear V3-loop peptide (WITO pV3) on autologous neutralization at two time points (week 29 and 37). The assays were performed by incubating the linear V3 peptide with macaque sera prior to addition to the pseudovirus stock. The asterisk denotes a p value <0.05, as assessed by two-tailed paired t-test.

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