Extended Data Fig. 10: Risks and 12-month burdens of incident post-acute COVID-19 composite cardiovascular outcomes compared to the historical control cohort by care setting of the acute infection.

Risks and burdens were assessed at 12 months in mutually exclusive groups comprising non-hospitalized individuals with COVID-19 (green), individuals hospitalized for COVID-19 (orange), and individuals admitted to intensive care for COVID-19 during the acute phase (first 30 days) of COVID-19 (blue). Composite outcomes consisted of cerebrovascular (stroke and TIA), dysrhythmias (atrial fibrillation, sinus tachycardia, sinus bradycardia, ventricular arrhythmias, and atrial flutter), inflammatory heart disease (pericarditis, myocarditis), ischemic heart disease (acute coronary disease, myocardial infarction, ischemic cardiomyopathy, and angina), other cardiac disorders (heart failure, non-ischemic cardiomyopathy, cardiac arrest, and cardiogenic shock), thrombotic disorders (pulmonary embolism, deep vein thrombosis, and superficial vein thrombosis), MACE (all-cause mortality, stroke, and myocardial infarction), and any cardiovascular outcome (incident occurrence of any cardiovascular outcome studied). Outcomes were ascertained 30 days after the COVID-19 positive test until the end of follow-up. The historical control cohort served as the referent category. Within the COVID-19 cohort, non-hospitalized (N = 131,612), hospitalized (N = 16,760); admitted to intensive care (N = 5,388); and historical control cohort (N = 5,859,411). Adjusted hazard ratios and 95% confidence intervals are presented. Length of the bar represents the excess burden per 1000 persons at 12 months and related 95% confidence intervals were also presented. MACE, major adverse cardiac events; TIA, transient ischemic attack.