Extended Data Fig. 10: Distributions of simulated embryo risk.
From: Whole-genome risk prediction of common diseases in human preimplantation embryos
Comparison of simulated distributions of odds ratios assuming linked and unlinked neighboring SNPs for one study couple (case ID 3). Atrial fibrillation demonstrates a bimodal distribution with linked SNPs with several simulated children predicted to have an OR of 2, consistent with predictions made on embryos (Extended Data Fig. 6). Simulations on linked SNPs used an approach described in Methods and Caballero et al.22.
