Extended Data Fig. 6: Variability in predicted disease risk across 11 additional conditions.
From: Whole-genome risk prediction of common diseases in human preimplantation embryos
a, Predicted relative risk of disease. b, Predicted absolute disease risk. Autoimmune conditions (Type 1 diabetes, Vitiligo) exhibit greater variability in predicted disease risk as has been previously reported. Note: Risk for the embryo in case ID 7 carrying the APC risk allele, rs1801155, is based solely on that allele. A competing hazards method (Gail et al 1989) was used to calculate the absolute risk for atrial fibrillation, coronary artery disease, prostate cancer and Type 2 diabetes. Age- and ethnicity-specific overall and disease specific mortality rates were taken from the CDC Wonder database (Underlying Cause of Death 1999–2019). Individuals with >20% admixture of African/Asian ancestry as determined using ELAI software were not considered in this analysis.
