Extended Data Fig. 5: Distribution of measured beta-cell function and insulin resistance across the tree. | Nature Medicine

Extended Data Fig. 5: Distribution of measured beta-cell function and insulin resistance across the tree.

From: Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes

Extended Data Fig. 5: Distribution of measured beta-cell function and insulin resistance across the tree.

Panel a & b: A visual representation of the phenotypic characteristics (log HOMA B and log HOMA IR) of n = 4150 patients at diagnosis of T2D from ADOPT trial. A mapping function was used to position individuals in ADOPT trial to the Scottish (reference) tree. Panel c shows the beta for the regression of each phenotype against the tree dimensions with 95% CI (n = 4150) – HOMA B showed a positive correlation with dimension 1 and negative correlation with dimension 2; while HOMA IR positively correlated with dimension 1 and negatively correlated with dimension 2.

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