Extended Data Fig. 4: Distribution of C-peptide, adiponectin, and leptin over the tree structure.
From: Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes
For a sub-population of Scottish patients, c-peptide (a), adiponectin (b) and leptin (c) measurements were available and are overlaid on the tree. The magenta color indicates higher values of the markers, and the green color indicates lower values (A-C). (d) shows the beta for the linear regression (with 95% CI) of C-peptide against the tree dimensions. (e) shows the beta for the linear regression (with 95% CI) of Adiponectin against the tree dimensions. (f) shows the beta for the linear regression (with 95% CI) of leptin against the tree dimensions. C-peptide and leptin showed a significant positive correlation with dimension 1 and negative correlation with dimension 2 whilst Adiponectin was significantly positively correlated with dimension 2 and negatively correlated with dimension 1.
