Fig. 5: VRC07-523LS neutralizing activity for baseline and rebound viruses.

a, VRC07-523LS IC80 values (µg ml⁻¹) are shown for each participant with baseline viruses shown in blue and rebound viruses in red (baseline and rebound viruses for 693–1969: nine and ten viruses; 693–2215: six and eight viruses; 693–7989: eight and ten viruses, respectively). Thick horizontal black lines indicate medians, and thin black lines indicate 25th and 75th percentiles. P values indicate significance from one-sided Wilcoxon rank-sum test. b, VRC07-523LS plasma ID₈₀ titers are shown for each participant. Same color scheme, number of viruses examined and statistics as in a. c, Comparison of CD4bs bNAb rebound ID₈₀ titers across different CD4bs bNAbs. Each point represents the per-participant median CD4bs bNAb ID₈₀ titers for rebound viruses from each study. Medians are shown by thick black lines and 25th and 75th percentiles by thin black lines. No significant differences were observed between any two studies. Studies: Bar-On et al.⁴, Caskey et al.³ and Lynch et al.¹.