Fig. 3: aHRs of severe clinical endpoints within strata defined by vaccination status.

Points and lines denote median estimates and accompanying 95% confidence intervals for the aHR of each endpoint, comparing individuals with Omicron versus Delta variant infection, in case strata defined by history of COVID-19 vaccination. Analyses are restricted to individuals diagnosed in outpatient settings by RT–PCR testing using the TaqPath COVID-19 Combo Kit; aHRs were estimated using Cox proportional hazards regression models, controlling for covariates listed in Supplementary Table 2 and stratifying on positive test date. Analyses include 23,305 individuals with Delta variant infection and 222,688 individuals with Omicron variant infection. Confidence intervals were obtained using Cox proportional hazards regression models. CI, confidence interval.