Extended Data Fig. 7: scRNA-seq characterization of CLL and RT.
From: Detection of early seeding of Richter transformation in chronic lymphocytic leukemia
a–d. UMAP visualization of tumor cells from all time points colored by annotation and tissue of origin. hi, high; lo, low; PB, peripheral blood; LN, lymph node; BM, bone marrow (left). Dot plot with the expression of key markers in each cluster. Color and size represent scaled mean expression and proportion of cells expressing each marker gene, respectively (middle-left). Violin plots showing the cell-cycle phase scores (S and G-to-M) for each cluster of cells (middle-right). UMAP visualization split by time point (right). ‘n’ refers to the total number of cells in that time point, and the percentage refers to the proportion of cells within RT clusters. e-i. Time point-specific UMAP visualizations for each case. RT seed cells are depicted in rose and with an increased size. j. UMAP visualization of case CLL9 from Penter et al.43 split by time point. PB, peripheral blood; BM, bone marrow.
