Extended Data Fig. 5

Data from PBMCs stimulated overnight in ex vivo (left graphs) or post-IVS (right graphs) IFNγ ELISpot with individual patient-specific peptides are shown for patient G1, G2, and G8. Graphs show individual duplicate values (SFU per 106 PBMCs) for each stimulation condition. Individual peptides with average responses >LOD (positive response) are shown in color (see mutation-specific coloring in graphs), and responses <LOD (negative response) are shown in clear circles.