Table 1 Baseline and disease characteristics by DL

From: Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results

 

DL1 (n = 3)

DL2 (n = 2)

DL3 (n = 3)

DL4 (n = 6)

Total (n = 14)

Age (yr), median (range)

72 (59–74)

70 (63–76)

51 (50–53)

55 (38–61)

59 (38–76)

Female gender, n (%)

1 (33)

1 (50)

1 (33)

1 (17)

4 (29)

ECOG, n (%)

 0

2 (67)

1 (50)

1 (33)

3 (50)

7 (50)

 1

1 (33)

1 (50)

2 (67)

3 (50)

7 (50)

Number of prior therapies, n (%)

 1

2 (67)

1 (50)

1 (33)

2 (33)

6 (43)

 2

1 (33)

1 (50)

2 (67)

4 (67)

8 (57)

Prior anti-PD(L)1 therapy, n (%)

 Yes

1 (33)

0 (0)

0 (0)

0 (0)

1 (7)

 No

2 (67)

2 (100)

3 (100)

6 (100)

13 (93)

Tumor types, n (%)

 MSS-CRC

0

1 (50)

2 (67)

4 (67)

7 (50)

 GEA

2 (67)

1 (50)

1 (33)

2 (33)

6 (43)

 NSCLC

1 (33)

0

0

0

1 (7)

  1. DL1, GRT-C901/GRT-R902 30 μg + i.v. nivolumab; DL2, GRT-C901/GRT-R902 100 μg + i.v. nivolumab; DL3, GRT-C901/GRT-R902 100 μg + i.v. nivolumab + s.c. ipilimumab; DL4, GRT-C901/GRT-R902 300 μg + i.v. nivolumab + s.c. ipilimumab.
  2. ECOG, Eastern Cooperative Oncology Group.