Extended Data Fig. 4: Effect of HLA alleles on DALYs.
From: Genetic risk factors have a substantial impact on healthy life years
Note that each gene is multiallelic, so the comparison of ‘1 vs 0 copies’ is more precisely the effect for having ‘1 copy of the allele in question and 1 average copy of other allele’ vs ‘having 0 copies of the allele in question and 2 average copies other alleles’. The interpretation of attributable DALYs in this context is not straightforward since these represent multiallelic loci. Estimates are based on 309,136 individuals (FinnGen). Error bars denote 95% confidence intervals.
