Fig. 3: DALYs attributable to carrying a deleterious rare variant in ACMG genes. | Nature Medicine

Fig. 3: DALYs attributable to carrying a deleterious rare variant in ACMG genes.

From: Genetic risk factors have a substantial impact on healthy life years

Fig. 3

The ClinVar37 burden contains all variants annotated as ‘pathogenic’ or ‘likely pathogenic’. *For BRCA1 and BRCA2 we only considered variants from ENIGMA38 annotated as ‘pathogenic’. The loss-of-function burden contains all variants annotated as pLOF with high confidence60. Estimates are based on 174,379 individuals from UKB. Error bars denote 95% CIs.

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