Extended Data Fig. 6: CMV status is not associated with prevalence of CD57-expressing CAR T cell populations or patient outcome. | Nature Medicine

Extended Data Fig. 6: CMV status is not associated with prevalence of CD57-expressing CAR T cell populations or patient outcome.

From: Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

Extended Data Fig. 6: CMV status is not associated with prevalence of CD57-expressing CAR T cell populations or patient outcome.

a, Percentage of circulating CD57+, CD4+CD57+, CD4+CD57+T-bet+, and CD8+CD57+T-bet+ T cells based on CyTOF data prior to axi-cel infusion stratified by patient cytomegalovirus (CMV) infection status (n = 30). b-e, Percentage of circulating CD57+ populations of CAR-negative (b-c) or CAR-positive (d-e) T cells on day 7 (b,d) or day 21 (c,e) stratified by patient CMV status (n = 31; n = 30 for CD4+ CAR+ T cells on day 21). f, Kaplan-Meier analysis of time to progression (TTP; left) and overall survival (OS; right) stratified by patient CMV status. Boxplots in (a-e) show quartiles with a band at median, whiskers indicating 1.5x IQR, and all observations overlaid as dots. P values are from two-sided Mann-Whitney U test.

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