Extended Data Fig. 3: CAR T cell hyperspheres associated with clinical response at 6 months.

a, Schematic for differential abundance analysis comparing circulating CAR T cells on day 7 between patients in CR or PD at 6 months following axi-cel infusion (n = 28). CAR T cells falling into the same region of space in all dimensions (hypersphere) were quantified to generate comparison metrics for patients in CR vs. PD at 6 months. b, Volcano plot showing hyperspheres generated as described in (a) that are significantly differentially abundant between patients in CR or PD at 6 months. c, Log2 fold change overlaid onto hyperspheres from (a) that were embedded into UMAP coordinates. Groups of hyperspheres that correspond to the 3 CAR T cell populations identified by the lasso model in Fig. 2d are highlighted. d, FDR-corrected P values overlaid onto hyperspheres from (c) and stratified by the statistical significance threshold of P < 0.05. e, Individual marker expression overlaid onto hyperspheres from (c).