Extended Data Fig. 8: Association between gene expression in NK cells and the percentage of viable tumor cells. | Nature Medicine

Extended Data Fig. 8: Association between gene expression in NK cells and the percentage of viable tumor cells.

From: Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial

Extended Data Fig. 8

The expression of different NK cell surface receptors was determined by scRNA-seq. Tumor samples collected at resection were classified into 3 groups of 5 samples each based on the percentage of viable tumor cells by pathologic analysis: low (≤25% viable tumor cells), middle (26%–50%), and high (>50%). UMAP plots of NK cells show normalized expression of several receptors in the 3 groups of viable tumor cell numbers. NK cells were down-sampled to have the same number of cells in each group. ILT2 is also known as LILRB1, ILT4 as LILRB2, NKG2A as CD159a, NKG2D as CD314 and KLRK1, KIR2DL1 as CD158a, KIR2DL3 as CD158b, KIR2DL4 as CD158d, KIR3DL1 as CD158e1, and KIR3DL2 as CD158k. CD, cluster of differentiation; ILT, immunoglobulin-like transcript; KIR, killer cell immunoglobulin-like receptor; KLR, killer cell lectin-like receptor; LILRB, leukocyte immunoglobulin-like receptor subfamily B; max, maximum; min, minimum; NK, natural killer; NKG2, natural killer group protein 2; scRNA-seq, single-cell ribonucleic acid sequencing; UMAP, uniform manifold approximation and projection.

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