Extended Data Fig. 6: Sensitivity of AF detection as function of PPG measurement frequency and AF burden.

Model describing the weekly sensitivity for detecting atrial fibrillation (AF) as a function of the number of measurements per week and the AF-burden. We used the timestamps of the available 300,509 PPG-measurements in order to calculate the frequency of measurements for the various parts of the day. Based on this frequency pattern we subsequently simulated PPG-measurements for increasing AF-burden (we consequently increased AF-burden from 1 h/week, [0.69% AF-burden] to 168 h / week [100% AF-burden] by 1 h steps and performed 10.000 simulations for each AF-burden step), which was defined as and finally calculated the sensitivity of the AF-detection. For this model, 89% sensitivity of the PPG-algorithm was assumed. With 2 measurements / day (according to the study protocol for the first 2 weeks) an AF-burden > 12.5% would be required to detect AF with > 80% sensitivity in one week. With 2 measurements / week (according to the study protocol from week 3 to month 6) an AF-burden > 62.5% would be required to detect AF with > 80% sensitivity in one week.