Extended Data Fig. 7: Longitudinal predictions of the clinical scales.
a. Comparison of the aggregate R2 of the leave-one-subject-out cross-validated predictions of the 6MWD at T + 6 months by the ethomic fingerprints from visit T vs the predictions by 6MWD at visit T. The leave-one-subject-out cross-validated prediction of the 6MWD at T + 6 months using the 6MWD at T months (red bar) was done on the combined cohort of KineDMD study (n = 13 subjects with 24 longitudinal visits) and Gemelli study (n = 44 subjects with 122 longitudinal visits). The leave-one-subject-out cross-validated prediction of the 6MWD at T + 6 months using the ethomic fingerprints at T months (blue bar) was done on the KineDMD cohort (n = 13 subjects, 24 visits). b and c are the corresponding plots for NSAA and PUL respectively. d. Scatter plot of the Myogrip from the visit at time T against the Myogrip from a visit at time (T + 6 months) from KineDMD study (n = 13 subjects, 23 visits). Myogrip was not collected from Gemelli study. e. Comparison of the aggregate RMSE of the leave-one-subject-out cross-validated predictions of the Myogrip at T + 6 months by the ethomic fingerprints from visit T and Myogrip at visit T. f-h. Actual vs prediction plot from the longitudinal prediction models of the clinical scales 6MWD (f), NSAA (g) and PUL (h) using ethomic fingerprints. Each point represents the actual vs predicted score for a patient’s visit.
