Fig. 3: KineDMD trial structure and cross-sectional predictions. | Nature Medicine

Fig. 3: KineDMD trial structure and cross-sectional predictions.

From: Wearable full-body motion tracking of activities of daily living predicts disease trajectory in Duchenne muscular dystrophy

Fig. 3: KineDMD trial structure and cross-sectional predictions.

a, Pictorial representation of the KineDMD clinical trial structure and the different types of predictions done in the study. b, Pictorial representation of the Gemelli and KineDMD studies showing the data source, measurement method and outcomes. c–e, Plots of actual versus predicted values for 6MWD (c), NSAA (d) and PUL (e). Cross-sectional predictions of these clinical scales were made using the ethomic fingerprints. Each point represents the actual versus predicted score for a patient’s visit. A LOSO cross-validation and Gaussian process regression were used to find a mapping between the ethomic fingerprints from the natural movement behavior of the patients with DMD and the different clinical scales of 6MWD (n = 17 ambulatory individuals, 37 visits), NSAA (n = 18 ambulatory individuals, 41 visits) and PUL (n = 21 individuals, 45 visits).

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