Fig. 5: Cumulative risk and burden of sequelae in people with one, two and three or more SARS-CoV-2 infections compared to noninfected controls.

Risk and 1-year excess burden of hospitalization, at least one sequela and sequelae by organ system are plotted. Incident outcomes were assessed from 30 d after the first positive SARS-CoV-2 test to the end of the follow-up. Results from one SARS-CoV-2 infection (n = 234,990), two SARS-CoV-2 infections (n = 28,509) and three or more SARS-CoV-2 infections (n = 1,023) versus noninfected controls (n = 5,334,729), in those with a first infection before the Omicron wave, are compared. Adjusted HRs (dots) and 95% CIs (error bars) are presented, as are the estimated excess burden (bars) and 95% CIs (error bars). Burdens are presented per 1,000 persons at 1 year of follow-up.